From Cairo to Lagos - still can't do? See maps.

Africa’s international road network has missing links, while administrative and regulatory barriers block existing connections - AfDB (African Development Bank infrastructureafrica.org for details)

The Trans-African Highway still has long gaps

Also:
...only 1 in 3 rural Africans has access to an all-season road;  but [roads] critical to raising agricultural productivity.
...in cities, road construction has not kept pace with urbanization...mobility problems caused by too few paved roads and inadequate public transportation systems.
...road freight will continue to be costly and inefficient until competition in the trucking industry is increased and barriers to trade are lifted.

Google Maps shows no gap, and suggests you could make the trip in a few days.  Maybe not advisable?  Then the more direct route takes you through a couple of war/strife zones.

Rail is worse: in the context of transcontinental travel, let's just say trains are nonexistent.  (Or do we just need a new map - this map is old)

You would think Lagos, Cairo, each with about 20million inhabitants, are not so far apart that they should 'feel' so far apart.  On my wish-list for 2020... Till then, thank God for air travel.  And the internet. 

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